Effects of solutol kolliphor and cremophor in polyethylene glycol 400 vehicle formulations in spraguedawley rats and beagle dogs. Kolliphor hs 15 as solubilizing agent hs 15are by the dissolution method to resolve its. The authors are current or former basf and cognis employees who have essentially. Coon,2 warren knudson, kathleen clodfelter, bing lu, and ronald s. You can find detailed information on our product range by looking up your industry or using our product finder.
Pharmaceuticalgrade ingredients for the dermatology. Simultaneous determination of kolliphor hs15 and miglyol. Kolliphor p 407 and kolliphor p188 were obtained from basf, us. Research article development and evaluation of atazanavir. An improved method to prepare an injectable microemulsion of the galaninreceptor 3 selective antagonist. Kolliphor hs 15 an enabler for parenteral and oral formulations. Pdf systemic delivery of alphaasarone with kolliphor hs. Discover basfs wide range of excipients for parenteral use meeting. Solutol hs 15, nontoxic polyoxyethylene esters of 12hydroxystearic acid, reverses multidrug resistance1 john s. Kolliphor ps 20 is its high hlb value more suitable as a solubilizer of poorly water soluble drug substances in either liquid or solid dosage forms. The development of this method started with the selection of a diluent that was suitable not only for dissolving kolliphor hs 15 and miglyol 812, but also for being compatible with the mobile phase.
Kolliphor ps 20 can also be used as solubilizer in softgel formulations. Basf, wyandotte, mi at 10 mgml approx imately 7 himwas analyzed using a beckman model hob liquid. Pdf solutol hs 15, nontoxic polyoxyethylene esters of 12. Ideal for solubilizing lowsolubility actives in microemulsions, it helps tackle even the toughest solubilization challenges. Preparation, characterization, and stability li liu,1,2 kai mao,1,2 wenting wang,1,2 hongchun pan,1,2,5 fen wang,3 min yang,4 and hong liu1,2,5 received 22 march 2015. In formulations that include poorly soluble actives, kolliphor p 188 can improve solubility, absorption and. Link to pdf containing technical information on solutol hs 15 from the basf chemical company.
It is used for manufacturing aqueous parenteral preparations with vitamins a, d, e and k, plus lipophilic apis such as propanidid, miconazole, alfadolone, alfaxalone. Description trehalose6,6dibehenate tdb is a synthetic analog of trehalose6,6dimycolate tdm, also known as cord factor. Stokes ah1, kemp dc, faiola b, jordan hl, merrill cl, hailey jr, brown re, bailey dw. Used in paste form by the pharma industry in human and veterinary injection formulations. Development and evaluation of atazanavir solid sedds. The authors present an update to the wyeth basf experience with the ipec novel excipient safety evaluation procedure. The package also included a cover letter requesting that pdg evaluate the information submitted and provide an independent safety evaluation for solutol hs15 to basf. Solutol hs15 as a novel excipient pharmaceutical technology. The drug was added to a 5ml capacity stoppered glass vial and mixed for 10 min with each component using a vortex mixer. It is suitable for usage in physical mixing, melt granulation, spray drying and hot melt extrusion processes.
Enhancement of solubility and oral bioavailability of. Whats more, kolliphor rh40 is almost tasteless making it ideal for oral applications. Kolliphor p 188 is an poloxamer that enables and enhances a wide range of functional applications. Moreover, kolliphor hs 15 has been included in the germany pharmacopoeia, the united states and the european pharmacopoeia. Kolliphor hs 15 an enabler for parenteral and oral.
Today we solve unmet formulation needs and offer intelligent solutions for today and tomorrows challenges in. Kolliphor hs 15 macrogol 15hydroxystearate sigmaaldrich. Datocopheryl polyethylene glycol succinatesolutol hs 15 mixed. Kolliphor hs15 was supplied by basf shanghai, china. Preparation and pharmacokinetics evaluation of oral self. Therapeutically, modern drugs are rarely given in a pure chemical state, so most active ingredients are combined with excipients or. The role of polymer excipients in hot melt extrusion a. Chemicals are produced in a broad range of rigid twocomponent. Systemic delivery of alphaasarone with kolliphor hs 15.
Key features of kolliphor tpgs based on naturalsource vitamin e from basf. Basf offer all functional materials required for a successful formulation using melt granulation. Today we solve unmet formulation needs and offer intelligent solutions for today and tomorrows challenges in drug formulation. A total of 15 female and 9 male beagle dogs marshall bioresources, north rose, new york were used in this study and were approximately 16 to 30 months of age and weighed 5 to 15 kg at the initiation of dosing. For instant and modified release applications, kolliphor p 188 can act as a stabilizer in oral suspensions. An improved method to prepare an injectable microemulsion of the. Tween 80, propylene glycol, peg 400 and peg 600 were obtained from sdfcl, mumbai. Macrogol 15hydroxystearate, polyethylene glycol 15 hydroxystearate, polyoxyethylated 12hydroxystearic acid, solutol hs 15 cas number 70142346. The impact of micellar compositions, the preparation condition, and the preparation method on size characteristics, the solubilization efficiency, and micellar stability were investigated. Since then we have continuously expanded our solution offer. Kolliphor hs 15 is a potent nonionic solubilizer and emulsifying agent, with low toxicity. If you place an order, you will be acknowledged with any corrected pricing. We will grow profitably and create value for society. Pdf a recently developed nonionic surfactant called solutol hs 15.
We are currently working diligently to update our website pricing information for the new year. Solutol hs 15 was purchased from basf ag ludwigshafen, germany. Kolliphor hs 15 is used in a recently fda approved parenteral drug. Kolliphor hs 15 is an exceptional solubilizer with attributes suited for parenteral and oral formulation of poorly soluble molecules. Systemic delivery of alphaasarone with kolliphor hs 15 improves its safety and therapeutic effect on asthma article pdf available in drug delivery 223 march 2014 with 334 reads.
An improved method to prepare an injectable microemulsion. This is how we create chemistry for a sustainable future. The microemulsion system selected from the phase diagram and optimized by central composite design ccd response surface method was transformed into solidsmedds ssmedds by lyophilization using sucrose as cryoprotectant. Our aspiration is to be the worlds leading chemical company for our customers.
Regulatory approval process for drug products containing. International journal of toxicology effects of solutol. Plastic cell culture dishes and plates were purchased from corning. In addition, it has been approved by cfda as an excipient for injection. Basf has been committed to the pharmaceutical industry since we introduced our original kollidon in the early 20th century. Aqueous solutions containing more than 20% kolliphor p 188 are thermoreversible, i. The dogs were identified uniquely by a breeders identification number tattooed in the. Sigma aldrich fine chemicals biosciences kolliphor hs 15. Gelucire 4414, kolliphor hs 15, kolliphor rh 40, labrasol, lauroglycol, were gifted from basf, mumbai. Sigma aldrich fine chemicals biosciences kolliphor hs 15 kolliphor hs 15. Solutol hs 15, nontoxic polyoxyethylene esters of 12. Aqueous solutions of kolliphor p 188 have newtonian flow properties that change to nonnewtonian behavior at higher concentrations.
As a consequence, it is primarily used in screening of new chemical entities nces and also used as a vehicle in delivery of molecules encapsulated in micelles or microemulsions. Through science and innovation we provide our customers with products to meet the current and future needs of business and society. Accelon is a breakthrough omega3 technology that significantly accelerates omega3 absorption, so you get more omega3 to where its needed. Kolliphor hs 15 is an exceptional solubilizer with attributes suited for parenteral and oral formulation of poorly. Kolliphor rh40 is widely used in selfemulsifying drug delivery systems sedds or microemulsifying systems smdds in combination with a cosolubilizer andor cosolvent. Tpgs is commonly used in pharmaceutical and nutraceutical formulations. The free polyethylene glycol can be determined by hplc.
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